Published: Fri, December 07, 2018
Medical | By Vicki Mclaughlin

Ever Baby Born Following A Uterus Transplant From A Deceased Donor

Ever Baby Born Following A Uterus Transplant From A Deceased Donor

The world's first baby born by a uterus transplant from a deceased donor is healthy and nearing her first birthday, according to a new case study published Tuesday in the Lancet.

The patient 32 years old was born without a uterus.

All that is known about her donor is that she was 45, had three successful vaginal deliveries, and had granted use of her organs prior to her death from brain haemorrhage.

Five months after the transplant her body showed no signs of rejecting the uterus and her fertilised eggs were implanted two months later.

The girl born in the Brazilian case was delivered via caesarean section at 35 weeks and three days, and weighed 2,550 grams, the case study said.

It comes after 10 previously known cases of uterus transplants from deceased donors - in the United States, the Czech Republic and Turkey - failed to produce a live birth.

Since then there have been 39 such procedures, resulting in 11 live births. But according to the authors, they are the first to have accomplished it with a uterus from a deceased donor (there was a documented attempt in 2011, but the pregnancy ended in miscarriage). The mother, whose uterus was removed in the same surgical procedure, is also healthy, the study added.

These include the need to use several immune-suppressing drugs throughout the 9 months of pregnancy, which may have side effects on both the mom and the baby; having to deliver the baby and then remove the uterus in a cesarean hysterectomy procedure; a high rate of organ rejection; and a lengthy surgery that requires a multi-disciplinary approach among doctors.

This Country Is Making All Public Transit Free
Sandwiched between France, Belgium and Germany, from which nearly 200,000 people enter it daily to work, the Guardian reports. Children and young people under the age of 20 already travel for free and many qualify for an annual mPass, which costs €150.

Lawmakers considering stopgap spending measure ahead of government funding deadline
Even some Republicans balk at spending more than the $1.6 billion for fencing and other security improvements already provided. President Trump is demanding $5 billion for the wall, but top Democratic leaders say they can't support that level of money.

Trump urges against oil production cut ahead of OPEC meeting
But Washington gave sanctions waivers to some buyers of Iranian crude, further raising fears of an oil glut next year. On Thursday, Brent futures fell more than 2% as traders began to doubt Opec would deliver a significant cut.

Part of the challenge in transplanting a uterus from a deceased donor is that the process - obtaining an organ, matching it to a recipient based on blood type and other qualities, and completing the operation - can take time.

The first childbirth following uterine transplantation from living donors occurred in Sweden in September 2013.

Doctor Andraus (far left) was the head transplant surgeon involved in the surgery to transplant the donated uterus. After the transplant, her period returned after 37 days.

Research has since continued, with informed volunteers still opting to go through the discomfort and potential trauma in the hopes of giving birth. Uterine transplants can sidestep these issues and allow women who otherwise wouldn't be able to have the chance to carry their own pregnancies.

At least a dozen children worldwide have been born to women with transplanted uteri donated by a living relative, but never one from a deceased donor. Fifteen were fertilised, with 8 resulting in embryos that were subsequently preserved for later implantation.

Doctors implanted the fertilized eggs seven months after the procedure. No complications were reported other than a kidney infection at 32 weeks that was treated with antibiotics.

Richard Kennedy, president of the International Federation of Fertility Societies (IFFS), said: "The IFFS welcomes this announcement which is an anticipated evolution from live donors with clear advantages and the prospect of increasing supply for women with hitherto untreatable infertility".

The baby girl was seven months and 20 days old, weighing 7.5kg when the researchers wrote their report.

Like this: