Published: Wed, March 06, 2019
Medical | By Vicki Mclaughlin

Second Patient Cleared of the Virus That Causes AIDS

Second Patient Cleared of the Virus That Causes AIDS

Not coincidentally, the stem cells that both patients received in the transplant came from donors with a double set of this rare CCR5 mutation. To do this in others, exact match donors would have to be found in the tiny proportion of people - majority of northern European descent - who have the CCR5 mutation that makes them resistant to the virus. The patient remained on anti-HIV drugs to prevent the virus from replicating for almost 1.5 years after the transplant; because HIV tends to hide in cells in a dormant phase and reactivate years later, Gupta wanted to be sure that as much of the virus as possible was destroyed with the drugs.

In 2003, the male patient was diagnosed with HIV infection and developed an Aids defining cancer, advanced Hodgkin's Lymphoma, in 2012.

The man is being called "the London patient", because his case is similar to the first known case of a functional cure of HIV - in an American man, Timothy Brown, who became known as the Berlin patient. "However, this is a long time to be in remission off ART". However, because HIV remained undetectable, he is still considered clinically cured of his infection, according to his doctors. Several patients who have received such transplants since Brown's successful treatment have died of the underlying cancer, several HIV researchers noted. Brown's experience suggested that HIV might one day be curable; it fuelled various efforts by researchers and institutions to focus on HIV cure research. Because of these risks, stem cell transplants haven't been considered a treatment option for HIV patients.

Brown's bone marrow donor also had the CCR5 mutation - something Dr. Sharon Lewin (a professor of medicine and director of the Peter Doherty Institute for Infection and Immunity, who was not involved in the London patient's treatment) told CNN is "exciting" given the remission period of the new patient compared with Brown's case.

Stem-cell transplants are expensive and risky, because they involve wiping out a patient's immune system with powerful drugs or radiation and then reconstituting it.

Legendary Hulk Hogan Foe King Kong Bundy Dies at 61
Instead of being satisfied with a simple three count, Bundy had the signature move of making the referee to count to five instead. On the TV show he played as his wrestling character in one episode and as Uncle Irwin, Peggy Bundy's brother, in another.

Kylie Jenner is officially the world's youngest billionaire
Kylie's sales recently shot up to 360 million dollars in the year 2018 which has made her reach a fortune of ten - figures. Her success can mainly be credited to her sensational make-up line Kylie cosmetics which has enjoyed unbelievable success.

Hillary Clinton says she won't run for US president in 2020
The former secretary of state said she was deeply troubled by the state of the country but nevertheless would not stand again. Clinton told News 12 Westchester that she's told every candidate she's met with so far to not take "anything for granted".

A bone-marrow stem cell transplant has led to a patient with human immunodeficiency virus (HIV) going into long-term remission, meaning he might become the second person to be cured of the disease.

"HIV Is Cured In 2nd Patient, Doctors Report, Such great news for so many". Notable differences were that the Berlin Patient was given two transplants and underwent total body irradiation, while the United Kingdom patient received just one transplant and less intensive chemotherapy. CCR5 is also the gene that Chinese researcher He Jiankui tweaked in embryos to give them a genetically-engineered resistance to HIV infection throughout their lifetimes. He notes that the Berlin patient and the London patient had similar side effects after the treatment.

Although the finding is exciting, it is not offering up a new treatment for the millions of people around the world living with HIV.

"At the moment the only way to treat HIV is with medications that suppress the virus, which people need to take for their entire lives, posing a particular challenge in developing countries".

"We can try to tease out which part of the transplant might have made a difference here, and allowed this man to stop his anti-viral drugs".

Like this: